Professor Vadym Kavsan
List of the most essential publications
  1. Dmitrenko, V.V., Shostak, K.O., Boyko, O.I., Homenko, O.V., Rozumenko, V.D., Malisheva, T.A., Shamayev, M.I., Zozulya, Y.P., and Kavsan, V.M. (2005) Reduction of the transcription level of the mitochondrial genome in human glioblastoma. Cancer Letters 218, 99-107.
  2. Dmitrenko, V.V., Shostak, K.O., Boyko, O.I., Homenko, O.V., Rozumenko, V.D., Malisheva, T.A., Shamayev, M.I., Zozulya, Y.P., and Kavsan, V.M. (2004) Changes in the expression of mitochondrial genes in human glioblastoma. Biopolymers and Cell 20, 34-40 (Ukraine).
  3. Kavsan, V.M., Shostak, K.O., Dmitrenko, V.V., Chausovskiy, T.I., Zozulya, Y.P., Demotes-Mainard, J. (2004) Peculiarities of molecular events in human glial tumors revealed by serial analysis of gene expression (SAGE). Exp. Oncol 26, 196-204.
  4. Shostak, K., Labunskyy, V., Dmitrenko, V., Malisheva, T., Shamayev, M., Rozumenko, V., Zozulya, Yu., Zehetner, G., and Kavsan, V. (2003) HC gp-39 gene is upregulated in glioblastomas. Cancer Lett. 198, 203-210.
  5. Shostak, K.O., Dmitrenko, V.V., Garifulin, O.M., Rozumenko, V.D., Homenko, O.V., Zozulya, Y.P., Zehetner, G., and Kavsan, V.M. (2003) Downregulation of putative tumor suppressor gene TSC-22 in human brain tumors. J. Surg. Oncol. 82, 57-64.
  6. Garifulin, O.M., Dmitrenko, V.V., and Kavsan, V.M. (2003) Molecular mechanisms of astrocytic gliomas cancerogenesis. Biopolymers and Cell 19, 19-30 (Ukraine).
  7. Palamarchuk, A., Gritsenko, O., Holthuizen, P., Sussenbach, J., Caelers, A., Reinecke, M., and Kavsan, V. (2002) Complete nucleotide sequence of the chum salmon insuline-like growth factor II gene. Gene 295, 223-230.
  8. Senyuk, O.F., Kavsan, V.M., Mueller, W.E., Schroeder, H.C. (2002) Long-term effects of low-dose irradiation on human health. Cell Mol. Biol. 48, 393-409.
  9. Garifulin, O.M., Shostak, K.O., Dmitrenko, V.V., Rozumenko, V.D., Homenko, O.V., Zozulya, Yu.A., Zehetner, G., and Kavsan, V.M. (2002) Increased expression of SOX-2 and HC gp-39 genes in astrocytic tumours. Biopolymers and Cell 18, 324-329 (Ukraine).
  10. Zozulya, Yu.A., Shostak, K.A., Garifulin, O.M., Rozumenko, V.D., Khomenko, A.V., Dmitrenko, V.V., and Kavsan, V.M. (2002) Role of changes in gene expression in the development of human brain gliomas. Vopr Neirokhir Im N N Burdenko 2, 43-50 (Russia).
  11. Palamarchuk, A.Y., Kavsan, V.M., Sussenbach, J.S., and Holthuizen, P.E. (2001) The chum salmon insulin-like growth factor II promoter requires Sp1 for its activation by C/EBPb . Mol. Cell. Endocrinol. 172, 57-67.
  12. Filenko, N.A., Shklyaruk, G.M., Butenko, G.M., and Kavsan, V.M. (2001) Plasmid mediated expression of human growth hormone increased splenocytes proliferative response in vivo. Ukr. Biokhim. Zh. 73, 30-33.
  13. Shostak, K.O., Dmitrenko, V.V., Garifulin, O.M., Rozumenko, V.D., Homenko, O,V., Zozulya, Yu.A., Zehetner, G., and Kavsan, V.M. (2001) Potential suppressor role of TSC-22 gene in human brain tumours. Biopolymers and Cell (Ukraine) 17, 152-159.
  14. Kavsan,V.M., Dmitrenko, V.V., Shostak, K.O., Marusyk, A.M.,and Zozulya, Y.P.(2001) Molecular genetics of gliomas. IN: "Genetics and Selection in the Ukraine at the Frontier of Millenium", Kiev: Logos, v. 1, 333-351.
  15. Moureau C., Moynier M., Kavsan V., Montagnier L., and Bahraoui E. (2000) Specificity of anti-Nef antibodies produced in mice immunized with DNA encoding the HIV-1 nef gene product. Vaccine 18, 333-341.
  16. Schroeder, H.C., Shostak, K., Gamulin, V., Lacorn, M., Skorokhod, A., Kavsan, V., and Mueller, W.E.G. (2000) Purification, cDNA cloning and expression of a cadmium-unducible cysteine-rich metallothionein-like protein from the marine sponge Suberites domuncula. Marine Ecol. Progr. Series 200, 149-157.
  17. Tassone, F., Lucas, R., Slavov, D., Kavsan, V., Crnic, L., and Gardiner, K. (1999) Gene expression relevant to Down syndrome: problems and approaches. J.Neural.Transm.[Suppl.] 57, 179-195.
  18. Palamarchuk, A.Y., Kavsan, V.M., Sussenbach, J.S., and Holthuizen, P.E. (1999) The chum salmon IGF-II gene promoter is activated by hepatocyte nuclear factor 3Я. FEBS Lett. 446, 251-255.
  19. Schroder, H.C., Perovic, S., Kavsan, V., Ushijima, N., and Muller, W.E.G. (1998) Mechanisms of PrionSc- and HIV-I gp120 induced neuronal cell death. Neuro Toxicology 19, 683-688.
  20. Moynier, M., Kavsan, V., Gales, C., Montagnier, L., and Bahraoui, E. (1998) Characterization of humoral immune responses induced by immunization with plasmid DNA expressing HIV-1 Nef accessory protein. Vaccine 16, 1523-1530.
  21. Dmitrenko, V.V., Shostak, K.O., Garifulin, O.M., Zozulya, Yu.A., and Kavsan, V.M. (1998) Changes of gene expression in human brain astrocytic tumors. Exp. Oncol. (Ukraine) 20, 191-197.
  22. Grebenjuk, V.A., Anoprienko, O.V., Skorokhod, A.S., Marichev, I.L., and Kavsan, V.M. (1998) Genetic characterization of HIV-1 variants in Ukraine. Biopolymers and Cell (Ukraine) 4, 277-285.
  23. Palamarchuk, A.Yu., Holthuizen, P.P., Muller, W.E.G., Sussenbach, J.S., and Kavsan, V.M. (1997) Organization and expression of the chum salmon insulin-like growth factor II gene, FEBS Lett. 416, 344-348.
  24. Dmitrenko, V., Garifulin, O., and Kavsan, V. (1997) Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. Gene 197, 161-163.
  25. Dmitrenko, V.V., Garifulin, O.M., Shostak, K. A., Smikodub A.I., and Kavsan, V.M. (1996) Characterization of different mRNA types expressed in human brain. Cytology & Genetics (Ukraine), 30, 41-47.
  26. Kulik, V. P., Kavsan, V.M., van Schaik, F. M.A., Nolten, L. A., Steenbergh, P. H., and Sussenbach, J. S. (1995) The promotor of the salmon insulin-like growth factor I gene is activated by hepatocyte nuclear factor 1. J. Biol. Chem. 270, 1068-1073.
  27. Bek, A., Muller, W.E.G., Seve, A.-P., Kavsan, V., and Schroder, H.C. (1995) REV protein suppression of complex formation between nuclear proteins and rev-responsive element-containing RNA of human immunodeficiency virus-1. Int. J. Biochem. Cell Biol. 27, 1317-1329.
  28. Dmitrenko, V.V., Garifulin, O.M., Smikodub, A.I., and Kavsan, V.M. (1995) Analysis of human genome expression using cDNA libraries of different tissues. Cytology & Genetics (Ukraine) 29, 64-71.
  29. Kavsan, V.M. (1995) Splicing. Chemical Encyclopedia (Russia), 4, 810-812.
  30. Kavsan, V.M., Grebenjuk, V.A., Koval, A.P., Scorohod, A.S., Roberts, C.P., and LeRoith, D. (1994) Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. DNA Cell Biol. 13, 555-559.
  31. Koval, A.P., Kulik, V., Duguay, S., Plisetskaya, E., Adamo, M.,Roberts, Ch., LeRoith, D., and Kavsan, V.M.(1994)Characrerization of a salmon insulin-like growth factor I promotor. DNA Cell Biol. 12, 1057-1062.
  32. Kavsan, V.M., Koval, A.P., and Palamarchuk, A.Ju. (1994) Growth hormone pseudogene in salmon genome. Gene 141, 301- 302.
  33. Rynditch, A.V., and Kavsan, V.M. (1994) Generation of new avian sarcoma viruses. Sov. Sci. Revs./ Section D. Physicochem. Biol., Harwood Academic Publishers GmbH, Yverdon, 1-97.
  34. Kavsan, V.M., Koval, A.P., Grebenjuk, V.A., Chan, Sh, J. Roberts, Ch.T., and LeRoith, D. (1994) Structure of the chum salmon insulin like-growth factor I gene. DNA Cell Biol. 12, 729-737.
  35. Kavsan, V.M., Koval, A.P., Petrenko, A.I., Roberts, Ch.T., and LeRoith, D. (1993) Two insulin genes are present in the salmon genome. Biochem. Biophys. Res. Commun. 191, 1373-1378.
  36. LeRoith, D., Kavsan, V.M., Koval, A.P., and Roberts, Ch. (1993) Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach. Mol. Reprod. Dev. 35, 4, 332-338.
  37. Kashuba, V.I., Kavsan, V.M., Rynditch, A.V., Lazurkevitch, Z.V., Zubak, S.V., Popov, S.V., Dostalova, V., and Hlozanek, I. (1993) Complete nucleotide sequence of duck adapted Rous sarcoma virus variant. Molecular Biology (Russia) 27, 1-19.
  38. Dmitrenko, V.V.,and Kavsan, V.M. (1991) Variability of polyadenilation sites in mRNAs from human fetal liver. FEBS Lett. 280, 284-286.
  39. Rynditch, A.V., Kashuba, V.I., Kavsan, V.M., Zubak, S.V., Dostalova, V., and Hlozanek, I (1990) Molecular principles of retrovirus adaptation: nucleotide sequence of Rous sarcom virus adapted to duck cells. Genetics (Russia) 26, 389-398.
  40. Dmitrenko, V.V., and Kavsan, V.M. (1990) Ambiguity of mRNA polyadenilation sites in embryonic human liver. Proc. Acad. Sci. USSR (Biochemistry Section) 313, 993-995.
  41. Dmitrenko, V.V., and Kavsan, V.M. (1989) Heterogeneity of polyadenilation site of mRNA encoding human serum albumin. Genetics (Russia) 26, 765-769.
  42. Koval, A.P., Petrenko, A.I., and Kavsan, V.M. (1989) Sequence of the salmon (Oncorhynchus keta) preproinsulin gene. Nucl. Acids Res. 17, 1758.
  43. Koval, A.P., Petrenko, A.I., Dmitrenko, V.V., and Kavsan, V.M (1989) Nucleotide sequence of preproinsulin gene in chum salmon. Molecular Biology (Russia) 23, 363-370
  44. Tomilin, N.V., and Kavsan, V.M. (1989) Genes transfer to mammalian cells by retrovirus vectors. Biopolymers and Cell (Ukraine) 5, 26-36.
  45. Rynditch, A.V., and Kavsan, V.M. (1989) Adaptation of oncogenic retroviruses to new hosts. Ukr.SSR Acad. Sci. Bull. 30-34.
  46. Ryndich, A.V., Kashuba, V.I., Kavsan, V.M., Zubak, S.V., and Glozhanek, I. (1989) Family of env genes of avian retroviruses: molecular analysis of Rous sarcoma virus adapted to duck cells. Molecular Biology (Russia) 23, 1076-1082.
  47. Zubak, S.V., Rynditch, A.V., Kashuba, V.I., Kavsan, V.M., and Hlozanek, I. (1989) The nucleotide sequence of env gene of duck-cells adapted Rous sarcoma virus. Nucl. Acids Res. 17, 6389.
  48. Shagun, S.V., Koval, A.P., and Kavsan, V.M. (1989) Determination of 5'- and 3'-nucleotide sequences of MAV-1 pol gene. Biopolymers and Cell (Ukraine) 5, 75-81.
  49. Kavsan, V.M. (1989) The determination of complete nucleotide sequence of human genome: projects and prospects. Biopolymers and Cell (Ukraine) 5, 16-25.
  50. Kashuba, V.I., Zubak, S.V., Lazurkevich, Z.V., Ryndich, A.V., Kavsan, V.M., Glozhanek, I., and Svoboda, J. (1989) Structure of a new transformation-defective mutant of Rous sarcoma virus. Proc. Acad. Sci. USSR (Biological Sciences Section) 304, 137-140.
  51. Koval, A.P., Petrenko, A.I., and Kavsan, V.M. (1988) Structure of the 5'-flanking region of the cloned preproinsulin gene of the Siberian salmon. Proc. Acad. Sci. USSR (Biochemistry Section) 301, 232-235.
  52. Kavsan, V.M. (1988) RNA-enzymes. Biopolymers and Cell (Ukraine) 4, 59-74
  53. Kavsan, V.M., Rudenko, N.K., Shneider, M.A., Kraevskii, A.A., and Beabealashvili, R.Sh. (1987) Suppression of the development of leukemia-sarcoma complex in birds with 3'- azido- 3'-deoxythymidine (AzT).A model for the screening and study of chemotherapeutic agents against retrovirus infections. Proc. Acad. Sci. USSR (Biochemistry Section) 96, 342-346.
  54. Shneider, M.A., Rudenko, N.K., Kavsan, V.M., Beabealashvili, R.S., Kraevskii, A.A., and Kukhanova, M.K. (1987) Effect of 3'-asido -2',3'-dideoxythymidine on experimental viral infections. Molecular Biology (Russia) 21, 706-800.
  55. Kavsan, V.M. (1987) Ambiguity of the eucariotic gene transcription boundaries. Biopolymers and Cell (Ukraine) 3, 115-127.
  56. Kutateladze, T.V., Kritzyn, A.M., Florentiev, V.Z., Kavsan, V.M., Chidgeavadze, Z.G., and Beabelashvilli, R.S. (1986) 3'-hydroxymethyl 2'-deoxynucleoside 5'-triphosphates are inhibitors highly specific for reverse transcriptase. FEBS Lett. 207, 205-212.
  57. Kavsan, V.M. (1986) Splicing. II. mRNA splicing in the nucleus. Molecular Biology (Russia) 20, 1186-1203.
  58. Kavsan, V.M. (1986) Splicing. I. Splicing of tRNA, rRNA, and mRNA in anelles. Molecular Biology (Russia) 20, 1-14.
  59. Kashuba, V.I., Kavsan, V.M., Petrenko, A.I., Dmitrenko, V.V., and Koval, A.P. (1986) Allelic polymorphism of the salmon preproinsulin gene. Molecular Biology (Russia) 20, 682-689.
  60. Staverskaya, O.V., Dobrovolskaya, G.N., Kavsan, V.M., Ishchenko, I.D., Rynditch, A.V., and Nazarenko, L.A. (1984) Isolation of reverse transcriptase of avian myeloblastosis virus in preparative amounts. Ukr. Biokhim.Zh. 56, 503-514.
  61. Kavsan, V.M., Petrenko, A.I., Brykov, V.A., and Sova, V.V. (1984) Insulin-specific sequences in the genomes of fish and invertebrates. Proc. Acad. Sci. USSR (Biochemistry Section) 274, 10-13.
  62. Kavsan, V.M., and Petrenko, A.I. (1984) Evolution of insulin genes and their introns. Folia biol.Prague, 32, 65-71.
  63. Svoboda, J., Rynditch, A.V., Mach, O., Hlozanek, I., Ruditch, V.V., and Kavsan, V.M. (1983) Virus-specific nuclear RNAs in mouse tumor cell lines transformed by Rous sarcoma virus. Folia biol.Prague 29, 273-283.
  64. Zolotuchin, S.V., and Kavsan, V.M. (1983) Structure of the animal globin genes. Advan. Biol. Chem. (USSR) 24, 148-169.
  65. Gren, A.Ja., Berzin, V.M., Zimanis, L.Ju., Apsalon, U.R., Vishnevskij, Ju.U., Janson, I.V., Dishler, A.V., Pudova, P.V., Smorodintsev, A.A., Jovler,V.I., Stepanova, A.N., Feldmane,G.J., Meldrais, J.A., Lozha, V.P., Kavsan, V.M., Efimov, V.A., and Sverdlov, E.D. (1983) The new type of leucocyte interferon. Proc. Acad. Sci. USSR, (Biochemistry Section) 269, 986-990.
  66. Sorokin, A.V., Skoblov, Ju.S., Mironov, A.A., Zlochevskij, M.L., Demjanova, N.G., Rebentish, B.A., Kozlov, Ju.I., Kavsan, V.M., Sova, V.V., and Debabov, V.G. (1983) Nucleotide sequence of the cloned Oncorhynchus keta insulin cDNA. Proc. Acad. Sci. USSR (Biochemistry Section) 269, 80-83.
  67. Kavsan, V.M., Petrenko, A.I., Rynditch, A.V., Dobrovolskaya, G.N., Sova, V.V., Prokopenko, I.V., Yurin, L.L., Demjanova, N.G., Zlochevskij, M.L., Kozlov, Yu.I., Naroditskaya, V.A., Skoblov, Yu.S., Rebentish, B.A., Sorokin, A.V., and Debabov, V.G. (1983) Synthesis, cloning and determination of structure of chum salmon preproinsulin cDNA. Molecular Biology (Russia) 17, 42-53
  68. Kavsan, V.M. (1983) Structure of globin-gene family as a model of eucaryotic gene structure. Molecular Biology (Russia) 17, 1-23.
  69. Kavsan, V.M. (1982) Plasmids. Soviet Ukrainian Encyclopedia, 8, 278.
  70. Sorokin, A.V., Petrenko, O.I., Kavsan, V.M., Kozlov, Yu.I., and Debabov, V.G. (1982) Nucleotide sequence analysis of the cloned salmon preproinsulin cDNA. Gene 20, 367-376.
  71. Ovchinnikov, Yu.A., Sverdlov E.D., Tsarev, S.A., Khodkova, E.M., Monastyrskaya, G.S., Efimov, V.A., Chakhmakhcheva, O.G., Solov'ev, V.D., Kuznetsov, V.P., and Kavsan, V.M., (1982) Cloning and identification of the human leukocyte interferon gene using synthetic oligonucleotides as primers and probes. Proc. Acad. Sci. SSSR (Biochemistry Section) 262, 27-30.
  72. Kavsan, V.M. (1982) Structure of globin genes in men with anomal hemoglobins. Cytology & Genetics (Ukraine) 16, 62-72.
  73. Kavsan, V.M., and Zolotuhin, S.B. (1982) The structure of human globin genes. Molecular Biology (Russia) 16, 1-20.
  74. Petrenko, A.I., Kavsan, V.M., Dobrovol'skaya, G.N., Kozlov Yu.I., Sova, V.V., and Debabov, V.G. (1981) Hybridization analysis of the correspondence of the nucleotide sequences of Siberian salmon insulin and human insulin cDNAs. Proc. Acad. Sci. USSR (Biochemistry Section) 257, 97-99.
  75. Demjanova, N.G., Zlochevsky, M.L., Kavsan, V.M., Kozlov, Y.I., Petrenko, A.I., Poljakova, N.E., Prokopenko, I.V., Rynditch,A.V., Skoblov, Y.S., Sova, V.V., Yurin, V.L., Jankovskij N.K., and Debabov, V.G. (1981) Cloning of the fish (Oncorhynchus keta) insulin gene in Escherichia coli. Proc. Acad. Sci. USSR (Biochemistry Section), 256, 35-38.
  76. Kavsan, V.M., and Kiselev, L.L. (1981) The expansion of possibilities of cDNA synthesis using the method of reverse transcription. The Successes of Modern Biol., 91, 323-333.
  77. Zolotukhin, S.B., Kopylova-Sviridova, T.N., Ryndich, A.V., Sukovatitsyn, V.V., Kavsan, V.M., and Fodor, I.I. (1980) Analysis of the proteins encoded by the recombinant plasmid contained rabbit globin gene structural sequences. Proc. Acad. Sci. USSR (Biochemistry Section) 254, 471-474.
  78. Kavsan, V.M., Ischenko, I.D., and Ryndich, A.V. (1980) Covalently bonded RNA-DNA molecules - the primary product of reverse transcription of heterogeneous nuclear RNAs from normal cells. Proc. Acad. Sci. USSR (Biochemistry Section) 250, 438.
  79. Rynditch, A.V., Ischenko, I.D., Zolotukhin, S.B., Hahn, H., Hunger, H.-D., and Kavsan, V.M. (1979) Reverse transcription of heterogeneous nuclear RNAs without adding the primer. Proc. Acad. Sci. Ukr. SSR, 954-958.
  80. Kavsan, V.M., Rynditch, A.V., and Manjakov, V.Ph. (1979) Synthesis and properties of DNA complementary to heterogeneous nuclear RNA. Hoppe-Seyler's Z. Physiol. Chem. 360, 1032-1033.
  81. Kavsan, V.M. (1979) Reverse transcription of eukaryotic and viral RNAs. Conditions for obtaining of long products. Molecular Biology (Russia) 13, 197-209.
  82. Kavsan, V.M. (1979) Synthesis of DNAs complementary to eukariotic mRNAs. Methods of Mol. Biol., Kiev, "Naukova Dumka", 201-213.
  83. Rynditch, A.V., Manyakov, V.F., Mazaev, A.G., Hahn, F., Hunger, H-D., Samarina, O.P., and Kavsan, V.M. (1979) Electron microscopic investigation of DNA products of reverse transcription. Molecular Biology (Russia) 13, 252-261.
  84. Sakharova, N.K., Ryndich, A.V., Kavsan, V.M., Goryunova, L.E., and Grechko, V.V. (1979) Messenger RNAs of mouse plasmocytoma. Reverse transcription and translation in cell-free protein-synthesizing system. Molecular Biology (Russia) 63, 127-136.
  85. Kavsan, V.M., Chumakov, M.P., Fleer, G.P. Rynditch, A.V., Lukshina, O.L., and Graevskaya, N.A. (1976) Comparative study of RNA-dependent DNA-polymerases (reverse transcriptases) of avian myeloblastosis and visna viruses. Proc. Acad. Sci. USSR (Biochemistry Section) 230, 401-403.
  86. Kavsan, V.M., and Rynditch, A.V. (1976) Determination of poly(A)-sequences in RNA with the help of reverse transcription. Proc. Acad. Sci. Ukr. SSR, 7, 630-632.
  87. Kavsan, V.M., Rynditch, A.V., Samarina, O.P., and Georgiev, G.P. (1975) DNA-synthesis on giant nuclear RNA by AMV DNA polymerase. Mol. Biol. Rep. 2, 203-207.
  88. Kavsan, V.M., Ryndich, A.V., Lukshina, O.L., Kok, I.P. Graevskaya, N.A., Samarina, O.P., Baisar, D., and Georgiev, G.P. (1975) DNA synthesis on the heterogeneous nuclear RNA template catalyzed by DNA polymerase of avian myeloblastosis virus. Molecular Biology (Russia) 9, 615-620.